Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1.

Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1.

The molecular mechanisms underlying chordoma pathogenesis are unknown. We due to this fact sought to determine novel mutations to higher perceive chordoma biology and to doubtlessly determine therapeutic targets. Given the comparatively excessive prices of entire genome sequencing, we carried out a centered genetic evaluation utilizing matrix-assisted laser desorption/ionization-time of flight mass spectrometer (Sequenom iPLEX genotyping). We examined 865 hotspot […]

Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1. Read More »